Trimethoprim-sulfamethoxazole and hyperkalemia
The trimethoprim component is the culprit due to a triamterene like effect. The problem is particularly serious in elders taking ACEIs or ARBs according to this study:Results During the 14-year study period, we identified 4148 admissions involving hyperkalemia, 371 of which occurred within 14 days of antibiotic exposure. Compared with amoxicillin, the use of trimethoprim-sulfamethoxazole was
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Beta-Blockers, Trimethoprim-Sulfamethoxazole, and the Risk of Hyperkalemia Requiring Hospitalization in the Elderly: A Nested Case-Control Study
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hyperkalemia emedicine nephrology
Antibiotics, such as pentamidine or trimethoprim/sulfamethoxazole 18; EACA 12 Trimethoprim-Sulfamethoxazole May Increase Risk for Hyperkalemia in the Elderly
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Drug-induced hyperkalemia: old culprits and new offenders. Am J Trimethoprim-Sulfamethoxazole May Increase Risk for Hyperkalemia in the Elderly
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