Trimethoprim-sulfamethoxazole and hyperkalemia
The trimethoprim component is the culprit due to a triamterene like effect. The problem is particularly serious in elders taking ACEIs or ARBs according to this study:Results During the 14-year study period, we identified 4148 admissions involving hyperkalemia, 371 of which occurred within 14 days of antibiotic exposure. Compared with amoxicillin, the use of trimethoprim-sulfamethoxazole was
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